Aleurites moluccana (L.) Willd.: características gerais, farmacológicas e fitoquímicas

Pamella Fukuda de Castilho; Kelly Mari Pires de Oliveira; Fabiana Gomes da Silva Dantas

doi:10.18593/eba.v19i2.21528

Authors

Pamella Fukuda de Castilho Federal University of Grande Dourados - Dourados Highway, Itahum Km 12, University City, Dourados, Mato Grosso do Sul, Brazil. https://orcid.org/0000-0002-5723-0507
Kelly Mari Pires de Oliveira Federal University of Grande Dourados - Dourados Highway, Itahum Km 12, University City, Dourados, Mato Grosso do Sul, Brazil. https://orcid.org/0000-0002-9897-7770
Fabiana Gomes da Silva Dantas Federal University of Grande Dourados - Dourados Highway, Itahum Km 12, University City, Dourados, Mato Grosso do Sul, Brazil. https://orcid.org/0000-0003-1651-9213

DOI:

https://doi.org/10.18593/eba.v19i2.21528

Keywords:

Noz-da-Índia, Medicinal plants, Biological activities

Abstract

Aleurites moluccana, belonging to the Euphorbiaceae family, is native to Indo-Malaysia but has been introduced in several countries and in Brazil it has adapted well to the South and South-west. It is popularly known by several names, such as: “Castanha Purgativa”, “Castenheira”, “Nogueira da Índia” and “Noz-da-Índia”. As for its morphology, it is considered a medium sized tree and contains fruits with large seeds of rough and oily aspect. Its favorable climate is tropical, however, it also develops in subtropical and semiaridregions, as the soil is able to settle in muds, sandy, slopes and even ravines. The adaptation of this plant to various conditions is one of the explanations of its wide geographical distribution. A. moluccana leaves, bark, trunk, sap and seeds are traditionally used for food, ornamentation and housing. In addition, A. moluccana has great prominence in folk medicine, being used in the treatment of ulcers, conjunctivitis, inflammation, cicatrization and analgesia. In this sense, this plant has become the objective of studies on its chemical components in order to find these secondary metabolites that have these pharmacological activities.

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Author Biographies

Pamella Fukuda de Castilho, Federal University of Grande Dourados - Dourados Highway, Itahum Km 12, University City, Dourados, Mato Grosso do Sul, Brazil.

Graduated in Biotechnology from the Federal University of Grande Dourados (2017). Master student in Health Sciences at the Federal University of Grande Dourados. Has experience in General Biology, focusing on Biotechnology, acting on the following subjects: applied microbiology and toxicology.

Kelly Mari Pires de Oliveira, Federal University of Grande Dourados - Dourados Highway, Itahum Km 12, University City, Dourados, Mato Grosso do Sul, Brazil.

Graduated in Biochemical Pharmacy from the State University of Maringá (1998), Master's degree in Food Science from the State University of Londrina (2000) and Ph.D. in Food Science from the State University of Londrina and University of MINHO, Portugal (2006).
She is currently Associate Professor at the Federal University of Grande Dourados. Has experience in Applied Microbiology, Environmental Microbiology, Mutagenic Activity and Plant Extract Antimicrobial and Mutagenic Activity.
Operates in environmental impact assessment in water sources through microbiological analysis and Ames Test, evaluates the virulence factors of microorganisms through adhesion tests and biofilm formation and antimicrobial susceptibility.

Fabiana Gomes da Silva Dantas, Federal University of Grande Dourados - Dourados Highway, Itahum Km 12, University City, Dourados, Mato Grosso do Sul, Brazil.

Graduated in Biological Sciences Bachelor (2007) from the Federal University of Grande Dourados (UFGD) and Degree (2009) from the University Center of Grande Dourados (UNIGRAN). Master in Environmental Science and Technology (2011) and PhD in Health Sciences (2019) both from UFGD. Has experience in Applied Microbiology and Mutagenesis. It acts in the evaluation of antimicrobial and mutagenic activity of medicinal plant extracts and new molecules.

References

Kinch MS, Hoyer D. A history of drug development in four acts. Drug discov today. 2015;20(10):1163-68. doi:10.1016/j.drudis.2015.04.003

Heyne K. Tumbuhan berguna indonesia. Badan Penelitian dan Pengembangan Kehutanan, Departemen Kehutanan. 1987;2:1188-89.

Cesca TG, Faqueti LG, Rocha LW, Meira NA, Meyre-Silva C, de Souza MM, et al. Antinociceptive, anti-inflammatory and wound healing features in animal models treated with a semisolid herbal medicine based on Aleurites moluccana L. Willd. Euforbiaceae standardized leaf extract: semisolid herbal. J. ethnopharmacol. 2012;143(1):355-62. doi:10.1016/j.jep.2012.06.051

Hoepers SM, Souza HGT, Quintão NLM, Santin JR, Cechinel Filho V, Silva RM, et al. Topical anti-inflammatory activity of semisolid containing standardized Aleurites moluccana L. WILLD (EUPHORBIACEAE) leaves extract. J. ethnopharmacol. 2015;173:251-55. doi:10.1016/j.jep.2015.07.024.

Quintão NLM, Meyre-Silva C, Silva GF, Antonialli CS, Rocha LW, Silva RML, et al. Aleurites moluccana (L.) Willd. leaves: mechanical antinociceptive properties of a standardized dried extract and its chemical markers. Evid Based Complement Alternat Med. 2011;2011. doi:10.1155/2011/179890

Souza VC, Lorenzi H. Botânica sistemática. Nova Odessa: Instituto Plantarum; 2008. p. 640.

Ribeiro RNS, Tourinho MM, Santana AC. Agro-environmental sustainability evaluation of productive agroforestry inutis in tidal river foodplains Cametá Pará. Acta Amaz. 2004;34(3). doi:10.1590/S0044-59672004000300003

Li S, Cui Y, Zhou Y, Luo Z, Liu J, Zhao M. The industrial applications of cassava: current status, opportunities and prospects. J. Sci. Food Agric. 2017;97(8):2282-90. doi: 10.1002/jsfa.8287

Oliveira-Júnior RG, Ferraz CA, Pontes M, Cavalcante NB, Araújo ECC, Oliveira AP, et al. Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome. Eur. J. Integr. Med. 2018;24:30-34. doi:10.1016/j.eujim.2018.10.011

Mavundza EJ, Mhlongo S, Cebekhulu S, Street RA, Bissessur A, Sitholeet Z, et al. Phytochemical screening of four South African poisonous medicinal plants of the family Euphorbiaceae. S. Afr. J. Bot. 2018;115:322. doi: 10.1016/j.sajb.2018.02.168

Innocent E, Joseph CC, Gikonyo NK, Nkunya MH, Hassanali A. Constituents of the essential oil of Suregada zanzibariensis leaves are repellent to the mosquito, Anopheles gambiae ss. J. Insect Sci. 2010;10(1). doi:10.1673/031.010.5701

Özbilgin S, Acıkara ÖB, Akkol EK, Süntar I, Keleş H, İşcan GS. In vivo wound-healing activity of Euphorbia characias subsp. wulfenii: Isolation and quantification of quercetin glycosides as bioactive compounds. J. ethnopharmacol. 2018. doi:10.1016/j.jep.2018.06.015.

Orellana-Cuéllar LR, Montañez JM, Moron MID, Orellana MAM, Benavente LAC, Aguilar VEL, et al. Toxicidad aguda de Aleurites moluccana por via oral en ratas Sprague-Dawley. CIMEL. 2014;19(1).

Lorenzi H. Árvores exóticas no Brasil: madeireiras, ornamentais e aromática. Nova Odessa: Instituto Plantarum. 2003; p. 368.

Orwa C, Mutua A, Kindt R, Simons A, Jamnadass RH. Agroforestree database: a tree species reference and selection guide. Version 4.0. Nairobi, KE: World Agroforestry Centre ICRAF; 2009.

Elevitch CR, Manner HI. Aleurites moluccana (kukui). Traditional trees of Pacific Islands: their culture, environment and use. Permanent Agriculture Resource. 2006; 41-56.

Krisnawati H, Kallio M, Kanninen M. Aleurites moluccana (L.) Willd.: ecology, silviculture and productivity. CIFOR. 2011.

Duke JA. Medicinal plants of the Bible. London: Trado-medic Books; 1983.

Bittencourt CMS. Análise fitoquímica e farmacológica de plantas medicinais selecionadas da flora catarinense: Aleurites moluccana, Bauhinia microstachya e Marrubium vulgare [tese]. [Florianópolis]: Universidade Federal de Santa Catarina; 2003. 180 p.

Wayson JT. Use of oil of Aleurites triloba or Aleurites moluccana in the treatment of leprosy. Arch Derm Syphilol. 1921;4(6):818. doi:10.1001/archderm.1921.02350250097009

Agência Nacional de Vigilância Sanitária. Resolução nº 322, de 6 de fevereiro de 2017. Brasília, 2017.

Meyre-Silva C, Mora TC, Biavatti MW, Santos AR, Dal-Magro J, Yunes RA, et al. Preliminary phytochemical and pharmacological studies of Aleurites moluccana leaves [L.] Willd. Phytomedicine. 1998;5(2):109-13. doi:10.1016/S0944-7113(98)80006-8

Meyre-Silva C, Yunes RA, Santos AR, Magro JD, Delle-Monache F, Cechinel-Filho V. Isolation of a C-glycoside flavonoid with antinociceptive action from Aleurites moluccana leaves. Planta med. 1999;65(3):293-94.

Quintão NLM, Antonialli CS, Silva GF, Rocha LW, Souza MM, Malheiros A, et al. Aleurites moluccana and its main active ingredient, the flavonoid 2 ″-O-rhamnosylswertisin, have promising antinociceptive effects in experimental models of hypersensitivity in mice. Pharmacol Biochem Behav. 2012;102(2):302-11. doi:10.1016/j.pbb.2012.05.005

Donald RM, Camargo SS, Meyre-Silva C, Quintão NLM, Cechinel Filho V, Bresolin TMB, et al. Development of an oral suspension containing dry extract of Aleurites moluccanus with anti-inflammatory activity. Rev. bras. Farmacogn. 2016; 6(1):68-76. doi:10.1016/j.bjp.2015.06.011

Quintão NLM, Rocha LW, Silva GF, Reichert S, Claudino VD, Lucinda-Silva RM, et al. Contribution of α, β-Amyrenone to the Anti-Inflammatory and Antihypersensitivity Effects of Aleurites moluccana (L.) Willd. Bio Med Res. Int. 2014;2014. doi:10.1155/2014/636839

Pedrosa RC, Meyre-Silva C, Cechinel Filho V, Benassi JC, Oliveira LF, Zancanaro V, et al. Hypolipidaemic activity of methanol extract of Aleurites moluccana. Phytother Res: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives. 2002; 16(8): 765-768. doi: 10.1002/ptr.1046.

Ado MA, Abas F, Mohammed AS, Ghazali HM. Anti-and pro-lipase activity of selected medicinal, herbal and aquatic plants, and structure elucidation of an anti-lipase compound. Molecules. 2013;18(12):14651-69. doi:10.3390/molecules181214651

Said T, Dutot M, Christon R, Beaudeux JL, Martin C, Warnet JM, et al. Benefits and side effects of different vegetable oil vectors on apoptosis, oxidative stress, and P2X7 cell death receptor activation. Invest Ophthalmol Vis Sci. 2007;48(11):5000-6. doi:10.1167/iovs.07-0229

Said T, Dutot M, Labbé A, Warnet JM, Rat P. Ocular burn: rinsing and healing with ionic marine solutions and vegetable oils. Ophthalmologica. 2009;223(1):52-9. doi:10.1159/000172618

Locher CP, Burch MT, Mower HF, Berestecky J, Davis H, Van Poel B, et al. Anti-microbial activity and anti-complement activity of extracts obtained from selected Hawaiian medicinal plants. J ethnopharmacol. 1995;49(1):23-32. doi:10.1016/0378-8741(95)01299-0

Locher CP, Witvrouw M, De Béthune MP, Burch MT, Mower HF, Davis H, et al. Antiviral activity of Hawaiian medicinal plants against human immunodeficiency virus type-1 (HIV-1). Phytomedicine. 1996;2(3):259-64. doi:10.1016/S0944-7113(96)80052-3

Yuliana ND, Jahangir M, Iqbal M, Wijaya CH. Screening of selected Asian spices for anti-obesity-related bioactivities. Food chem. 2011;126(4):1724-29. doi:10.1016/j.foodchem.2010.12.066

Liu H, Zhao Y, Li S-J, Ni W. Four New Podocarpane‐Type Trinorditerpenes from Aleurites moluccana. Helv Chim Acta. 2007;90(10):2017-23. doi:10.1002/hlca.200790209

Liu H, Di Y, Yang J, Teng F, Lu Y, Ni W, et al. Three novel 3, 4-seco-podocarpane trinorditerpenoids from Aleurites moluccana. Tetrahedron Lett. 2008;49(35):5150-51. doi:10.1016/j.tetlet.2008.06.088

Hui HW, Ho CT. An examination of the Euphorbiaceae of Hong Kong. Aust. J. Chem. 1968;21:1675-7. doi:10.1071/CH9682137

Meyre-Silva C, Mora TC, Santos ARS. A Triterpene and a Flavonoid Glycoside from Aleurites moluccana L. Willd. (Euphorbiaceae). Acta Farm Bonaer. 1997;16:169-72.

Silva DB, Fernandes EFA, Ferreira LS, Callejon DR, Guaratini T, Lopes JNC, et al. Megastigmanes from Aleurites moluccana (L.) Willd. (Euphorbiaceae). Biochem Syst Ecol. 2012;40:34-37. doi:10.1016/j.bse.2011.09.014

Shamsuddin T, Rahman W, Khan SA, Shamsuddin KM. Moluccanin, a coumarinolignoid from Aleurites moluccana. Phytochemistry. 1988;27(6):1908-9. doi: 0.1016/0031-9422(88)80480-1

Prabowo WC. Isolation and Characterization of 3-Acetylaleuritolic Acid and Scopoletin from Stem Bark of Aleurites moluccana (L. Willd). Int J Pharm Pharm Sci. 2013;5(3):851-53.

Alimboyoguen AB, Castro-Cruz KA, Shen C-C, Li W-T, Ragasa CY. Chemical constituents of the bark of Aleurites moluccana L. Willd. J Chem Pharm Res. 2014;6(5):1318-20.

Sotheeswaran S, Sharif MR, Moreau RA, Piazza GJ. Lipids from the seeds of seven Fijian plant species. Food chem. 1994;49(1):11-13. doi:10.1016/0308-8146(94)90225-9

Satyanarayana P, Singh SK, Kruthiventi AK, Rao GN. A new phorbol diester from Aleurites moluccana. Fitoterapia. 2001;72(3):304-6. doi:10.1016/S0367-326X(00)00314-2