Evaluation of the therapeutic effects of lectin obtained from Canavalia brasiliensis seeds (ConBr) in cutaneous lesions infected with Staphylococcus aureus
DOI:
https://doi.org/10.18593/evid.34475Keywords:
Plant bioactive compounds, Bacterial infections, Wound InfectionAbstract
Lectins of plant origin have gained prominence as immunomodulatory compounds; one example is the lectin extracted from Canavalia brasiliensis (ConBr). The lack of information related to the action of ConBr on infected wounds stimulated this research. Therefore, this study aimed to verify the therapeutic effects of the ConBr lectin on skin lesions infected by Staphylococcus aureus. The experimental wounds were induced on the back of Swiss mice, and the infectious process was caused by the addition of suspensions of S. aureus ATCC6538 (standard strain) or SA01 (clinical strain) to the newly produced wounds, which were treated with the lectin ConBr (200 µg /mL) and clinically evaluated for 10 days. After 3 and 10 days of treatment, the wounds were collected to evaluate bacterial load and nitric oxide (NO) levels. The use of ConBr on infected wounds could not contain the inflammation, regardless of the infecting strain. However, the area of the lesions was reduced. Lectin treatment also promoted a reduction in bacterin load, especially in wounds infected by the standard strain, where NO levels were increased by lectin treatment.
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