Células-tronco mesenquimais humanas e biomateriais como estratégia para terapia regenerativa cutânea: uma revisão integrativa

Luana Garcia; Daiany de Souza Dobuchak; João César  Zielak; Moira Pedroso Leão

doi:10.18593/evid.36579

Authors

Luana Garcia Universidade Positivo https://orcid.org/0009-0002-3187-5881
Daiany de Souza Dobuchak Curityba Biotech
João César Zielak Universidade Positivo
Moira Pedroso Leão Curityba Biotech

DOI:

https://doi.org/10.18593/evid.36579

Keywords:

Biomaterial, Mesenchymal Stem Cell, Regenerative Medicine

Abstract

Wound healing is a significant medical issue and a relevant public health concern. The pharmaceutical industry continues to seek effective therapeutic solutions that increase predictability and accelerate tissue repair processes. Mesenchymal stem cells (MSCs) are recognized for their healing properties and safety in cell therapies and are being applied to treat skin degradation conditions. To enhance this efficacy, tissue engineering uses biomaterials as a promising approach for cellular support, contributing to cell adhesion and proliferation. In this context, this integrative review investigates the effectiveness of combining MSCs with different biomaterials, consolidating evidence on the interaction between these components and their impact on skin treatment. Primary studies were selected across six scientific databases, employing descriptors that combined primary and secondary terms. The search systematization included evaluating titles, abstracts, and the complete reading of 24 publications, applying pre-defined inclusion criteria. The sample comprised seven studies. Data synthesis and qualitative analysis were conducted descriptively. The results of the studies, most indexed within the past 5 years, reveal a growing trend on the topic. Research from various countries, cellular origins, and biomaterials characteristics were recorded, indicating the diversity in approaches. Despite this, the outcomes were similar, demonstrating that the intended integration improves epithelial regeneration and fosters an environment favorable to cell migration. However, the authors highlight the need for further research to clarify the long-term effects and optimize the use of advanced therapies in this field, consolidating evidence on the interaction between MSCs and biomaterials and their ability to provide an effective and accessible solution for the management and treatment of hard-to-heal wounds.

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Author Biographies

Daiany de Souza Dobuchak, Curityba Biotech

Graduated in Biology from Faculdades Integradas Espírita (2007). Master's degree in Applied Biotechnology to Child and Adolescent Health from Faculdades Pequeno Príncipe (2013) and PhD in Applied Biotechnology to Child and Adolescent Health from Faculdades Pequeno Príncipe (2017). Experience in cell culture, primary cultivation, cell line culture, suspension culture, flow cytometry, immunocytochemistry, and surgical techniques in small rodents. Engaged in research in the field of regenerative medicine using stem cells in the development of advanced therapy products based on cells.

João César Zielak, Universidade Positivo

Holds a degree in Dentistry (1999), a Master's in Cellular Biology (2001), and a PhD in Industrial Biotechnological Processes in Health (2005), as well as specializations in Public Health (2008), Implant Dentistry (2012), and Orofacial Harmonization (2022). Professor of the Master's and Doctorate programs in Clinical Dentistry, Master's and Doctorate in Industrial Biotechnology (in Health), and the Dentistry undergraduate program at Universidade Positivo. Partner, Technical Director, and Senior Researcher at Curityba Biotech (since 2006, a company focused on technology and stem cell processing) and dentist (Zielak Odontologia). Has experience in the fields of Biotechnology and Dentistry, with an emphasis on Clinical Dentistry, Implant Dentistry, Orofacial Harmonization, Regenerative Medicine, Biomaterials, Histology, Health Innovation, and Stem Cells.

Moira Pedroso Leão, Curityba Biotech

PhD (2012) and Master's (2002) in Implant Dentistry from the Federal University of Santa Catarina. Holds a degree in Dentistry from the State University of Ponta Grossa (1990), a specialization in Dental Prosthetics (1999), and a specialization in Public Health from Universidade Positivo (2008). Served as a representative of the Federal Council of Dentistry (CFO) as a member of the Technical Advisory Chamber (CAT) in the areas of Cell Therapies and as a Full Member of the Permanent Commission on Biovigilance with the National Health Surveillance Agency (ANVISA). Currently, she is the Administrative Director and a researcher at Curityba Biotech and a researcher at IBRV - Research and Development Institute. She is a senior technical advisor to CFO on matters related to blood, tissues, stem cells, and their derivatives. Has experience in the field of Dentistry, with an emphasis on Regenerative Medicine (platelet-rich aggregates, stem cells, and biomaterials), primarily focusing on the following topics: implant dentistry, stem cells, regenerative medicine, and prosthetics, aiming to promote and restore health.

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