Cosmeceuticals based on atemoya peel extract: photoprotective and antimicrobial action

Authors

DOI:

https://doi.org/10.18593/evid.34921

Keywords:

Annona cherimola Mill.;, Annona squamosa L.;, Bioactive cream;, Hydroalcoholic extract;, Photoprotection.

Abstract

Cosmetic formulations with therapeutic activity have been the focus of research aimed at determining new applications and adding value to natural products. In this context, plant raw materials stand out for their richness in secondary metabolites, many of which have therapeutic properties. That includes the use of fruits considered unfit for sale for not meeting appearance standards for fresh fruit purchase and consumption. Thus, the present work developed cosmeceutical emulsions with atemoya peel extract containing a high content of phenolic compounds and their derivatives with photoprotective, antioxidant and bactericidal action. The emulsions prepared with 2%, 5% and 10% extracts were within the standards suggested for preliminary stability parameters of cosmetic formulations. All extracts and the emulsion containing 10% atemoya peel had a sun protection factor greater than 6 and antibacterial activity against Bacillus cereus and Pseudomonas aeruginosa. Finally, they met the ideal physical and sensory standards, presenting good texture and gloss, low stickiness, adequate residual perception, good spreadability and balanced sensation of freshness. The consumer demand for cosmeceuticals with effects for the prevention of premature aging, cancers caused by free radicals and inflammatory diseases justifies the research and development of multifunctional products, such as the one presented in this study.

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References

Abreu, T. S. (2020). Prospecção do potencial cosmecêutico da casca de atemoia. [Tese de Doutorado, Universidade Federal de Lavras].

Ahmad, I., & Beg, A. Z. (2001). Antimicrobial and phytochemical studies on 45 Indian medicinal plants against multi-drug resistant human pathogens. Journal of Ethnopharmacology, 74(2),113-123. https://doi.org/10.1016/S0378-8741(00)00335-4 DOI: https://doi.org/10.1016/S0378-8741(00)00335-4

Ambothi, K., Prasad, N. R., & Balupillai, A. (2015). Ferulic acid inhibits UVB-radiation induced photocarcinogenesis through modulating inflammatory and apoptotic signaling in Swiss albino mice. Food and Chemical Toxicology, 82, 72-78. https://doi.org/10.1016/j.fct.2015.04.031 DOI: https://doi.org/10.1016/j.fct.2015.04.031

Agência Nacional de Vigilância Sanitária [Anvisa]. (2012). Guia para Avaliação de Segurança de Produtos Cosméticos. (2ª ed.). Editora Anvisa. http://portal.anvisa.gov.br/documents/106351/107910/Guia+para+Avalia%C3%A7%C3%A3o+de+Seguran%C3%A7a+de+Produtos+Cosm%C3%A9ticos/ab0c660d-3a8c-4698-853a-096501c1dc7c

Agência Nacional de Vigilância Sanitária [Anvisa]. (2012). Regulamento Técnico Mercosul sobre Protetores Solares em Cosméticos e dá outras providências. Resolução n. 30, de 01 de Junho de 2012. http://portal.anvisa.gov.br/wps/wcm/connect/e15afe804c58f17fb8f0f8dc39d59d3e/Resolu%C3%A7%C3%A3o+RDC+N%C2%BA+30,+de+1%C2%BA+de+Junho+de+2012.pdf?MOD=AJPERES

Borges, I. V., Cavalcanti, L. S., Figueirêdo Neto, A., Almeida, J. R. G. S., Rolim, L. A., & Araújo, E. C. C. (2017). Identificação da fração antimicrobiana do extrato da Mimosa tenuiflora. Communicata Scientiae, 8(1), 155-164. https://doi.org/10.14295/CS.v8i1.1493 DOI: https://doi.org/10.14295/cs.v8i1.1493

Brazilian Pharmacopeia. (2019). Anvisa. Brasília. (6ª ed.). p. 92-105, 340-345. https://censos.ibge.gov.br/agro/2017/templates/censo_agro/resultadosagro/agricultura.html?localidade=35&tema=76231

Campos, W. R., Souza, D. C. M., Guimarães, D. G., Santos, V. L. A., Gonsalves, A. A., & Araújo, C. R. M. (2019). Mechanochemical synthesis of symmetric acyclic azines and determination of the uvb solar protection factor in vitro. Química Nova, 42(3), 305-312. https://doi.org/10.21577/0100-4042.20170321 DOI: https://doi.org/10.21577/0100-4042.20170321

Chen, W., & Wu, L. (2014). Chlorogenic acid suppresses interleukin-1β-induced inflammatory mediators in human chondrocytes. International Journal of Clinical and Experimental Pathology, 7(12), 8797-8801.

Chorilli, M., Udo, M. S., Rodrigues, L. A. P., Cavallini, M. E., & Leonardi, G. R. (2009). Avaliação sensorial de formulações fotoprotetoras contendo filtro solar de amplo espectro. Latin American Journal of Pharmacy, 28(3), 383-392.

CLSI Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. (2015). Approved Standard – 11th Edition. CLSI document M7-A10 [ISBN 1-56238-836-3]. CLSI, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898.

Da Silva, A. C. P., Santos, B. A. M. C., Castro, H. C., & Rodrigues, C. R. (2022). Ethylhexyl methoxycinnamate and butyl methoxydibenzoylmethane: Toxicological effects on marine biota and human concerns. Journal of Applied Toxicology, 42(1), 73-86. https://doi.org/10.1002/jat.4210 DOI: https://doi.org/10.1002/jat.4210

Elmets, C. A., Singh, D., Tubesing, K. A., Matsui, M., Katiyar, S., Katiyar, S., & Hasan Mukhtar, H. (2001). Cutaneous photoprotection from ultraviolet injury by green tea polyphenols. Journal of the American Academy of Dermatology, 44(3), 425-432. https://doi.org/10.1067/mjd.2001.112919 DOI: https://doi.org/10.1067/mjd.2001.112919

Exactitude Consultancy (2023). Mercado de produtos de proteção solar por tipo de produto (loções, sprays, bastões, lenços umedecidos, outros), canal de distribuição (hipermercados e supermercados, lojas de conveniência, varejo online, farmácias, outros) e região, tendências globais e previsão de 2023 a 2030. https://exactitudeconsultancy.com/pt/reports/34555/sunscreening-products-market/#:~:text=O%20mercado%20global%20de%20produtos,durante%20o%20per%C3%ADodo%20de%20previs%C3%A3o

Instituto Brasileiro de Geografia e Estatística [IBGE]. (2017). Censo Agro. Brasília. (6ª ed.). p. 92-105; 340-345. https://censos.ibge.gov.br/agro/2017/templates/censo_agro/resultadosagro/agricultura.html?localidade=35&tema=76231

Kazman, B. S. M. A., Harnett, J. E., & Hanrahan, J. R. (2022). Traditional Uses, Phytochemistry and Pharmacological Activities of Annonacae. Molecules, 27, 3462. https://doi.org/10.3390/molecules27113462 DOI: https://doi.org/10.3390/molecules27113462

Katiyar, S. K., Afaq, F., Perez, A., & Mukhtar, H. (2001). Green tea polyphenol (–)-epigallocatechin-3-gallate treatment of human skin inhibits ultraviolet radiation-induced oxidative stress. Carcinogenesis, 22(2), 287-294. https://doi.org/10.1093/carcin/22.2.287 DOI: https://doi.org/10.1093/carcin/22.2.287

Li, H-R., Habasi, M., Xie, L-Z., & Aisa, H. A. (2014). Effect of chlorogenic acid on melanogenesis of B16 melanoma cells. Molecules, 19(9), 12940-1248. https://doi.org/10.3390/molecules190912940 DOI: https://doi.org/10.3390/molecules190912940

Mansur, M. C. P. P. R., Leitão, S. G., Cerqueira-Coutinho, C., Vermelho, A. B., Silva, R. S., Presgrave, O. A. F., Leitão, A. A. C., Leitão, G. G., Ricci-Júnior, E., & Santos, E. P. (2016). In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts. Revista Brasileira de Farmacognosia, 26(2), 251-258. https://doi.org/10.1016/j.bjp.2015.11.006 DOI: https://doi.org/10.1016/j.bjp.2015.11.006

Matsui, M. S., Hsia, A., Miller, J. D., Hanneman, K., Scull, H., Cooper, K. D., & Baron, E. (2009). Non-sunscreen photoprotection: antioxidants add value to a sunscreen. Journal of Investigative Dermatology Symposium Proceedings, 14(1), 56-59. https://doi.org/10.1038/jidsymp.2009.14 DOI: https://doi.org/10.1038/jidsymp.2009.14

Moraes, I. V. M. (2016). Extração de compostos bioativos da gravioleira (Annona muricata L.) e concentração dos extratos por ultra e nanofiltração. Tese, Unicamp. http://taurus.unicamp.br/bitstream/REPOSIP/321387/1/Moraes_IngridVieiraMachadode_D.pdf

Munhoz, V. M., Lonni, A. A. S. G., Mello, J. C. P., & Lopes, G. C. (2012). Avaliação do fator de proteção solar em fotoprotetores acrescidos com extratos da flora brasileira ricos em substâncias fenólicas. Revista de Ciências Farmacêuticas Básica e Aplicada, 33(2), 225-232.

R Development Core Team. (2011). R: A language and environment for statistical computing. R Foundation for Statistical Computing, Viena. http://www.R-project.org

Saija, A., Tomaino, A., Trombetta, D., Pasquale, A., Uccella, N., Barbuzzi, T., Paolino, D., & Bonina, F. (2000). vitro and in vivo evaluation of caffeic and ferulic acids as topical photoprotective agents. International Journal of pharmaceutics, 199(1), 39-47. https://doi.org/10.1016/S0378-5173(00)00358-6 DOI: https://doi.org/10.1016/S0378-5173(00)00358-6

Seok, J. K., & Boo, Y. C. (2015). p-Coumaric acid attenuates UVB-induced release of stratifin from keratinocytes and indirectly regulates matrix metalloproteinase 1 release from fibroblasts. Korean Journal of Physiology and Pharmacology, 19(3), 241-247. https://doi.org/10.4196/kjpp.2015.19.3.241 DOI: https://doi.org/10.4196/kjpp.2015.19.3.241

Souyoul, S. A., Saussy, K. P., & Lupo, M. P. (2018). Nutraceuticals: a review. Dermatology and Therapy, 8(1), 5-16. https://doi.org/10.1007/s13555-018-0221-x DOI: https://doi.org/10.1007/s13555-018-0221-x

Surini, S., Mubarak, H., & Ramadon, D. (2018). Cosmetic serum containing grape (Vitis vinifera L.) seed extract phytosome: Formulation and in vitro penetration study. Journal of Young Pharmacists, 10(2), 51. https://doi.org/10.5530/jyp.2018.2s.10 DOI: https://doi.org/10.5530/jyp.2018.2s.10

Taofiq, O., González-Paramás, A. M., Barreiro, M. F., & Ferreira, I. C. F. R. (2017). Hydroxycinnamic acids and their derivatives: cosmeceutical significance, challenges and future perspectives, a review. Molecules, 22(2), 281. https://doi.org/10.3390/molecules22020281 DOI: https://doi.org/10.3390/molecules22020281

Taofiq, O., Heleno, S. A., Calhelha, R. C., Fernandes, I. P., Alves, M. J., Barros, L., González-Paramás, A. M., Ferreira, I. C.F.R., & Barreiro, M. F. (2019). Phenolic acids, cinnamic acid, and ergosterol as cosmeceutical ingredients: Stabilization by microencapsulation to ensure sustained bioactivity. Microchemical Journal, 147, 469-477. https://doi.org/10.1016/j.microc.2019.03.059 DOI: https://doi.org/10.1016/j.microc.2019.03.059

Thakker, K. D., & Chern, W. H. (2003). Development and validation of in vitro release tests for semisolid dosage forms-case study. Dissolution Technologies, 10, 10-16. https://doi.org/10.14227/DT100203P10 DOI: https://doi.org/10.14227/DT100203P10

United States Pharmacopeia and National Formulary (USP 41-NF 36). (2018). Rockville, MD: United States Pharmacopeial Convention. https://www.uspnf.com/

Xuan, S. H., Lee, K. S., Jeong, H. J., Park, Y. M., Ha, J. H., & Park, N. S. (2019). Cosmeceutical activities of ethanol extract and its ethyl acetate fraction from coffee silverskin. Biomaterials Research, 23(2), 2. https://doi.org/10.1186/s40824-018-0151-9 DOI: https://doi.org/10.1186/s40824-018-0151-9

Žilius, M., Ramanauskienė, K., & Briedis, V. (2013). Release of propolis phenolic acids from semisolid formulations and their penetration into the human skin in vitro. Evidence-Based Complementary and Alternative Medicine, 2013, 958717. https://doi.org/10.1155/2013/958717 DOI: https://doi.org/10.1155/2013/958717

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Published

04/14/2025

How to Cite

Abreu, T. S. de, César, P. H. S., Gonçalves, M. C., Piccoli, R. H., & Marcussi, S. (2025). Cosmeceuticals based on atemoya peel extract: photoprotective and antimicrobial action. Evidence, 24, e34921. https://doi.org/10.18593/evid.34921

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Section

Innovation