O potencial farmacológico e fitoterápico de plantas medicinais contra a tuberculose no Brasil

Ruan Lucas Costa Bastos; Lorena Araújo da Silva Brigel; Rebecca Clara Brasil Leite Mesquita; Lucas Eloy Veras Santos; Thalyson Costa Martins; Eduardo Martins de Sousa

doi:10.18593/evid.34545

Authors

Ruan Lucas Costa Bastos Uniceuma https://orcid.org/0009-0000-7440-6116
Lorena Araújo da Silva Brigel
Rebecca Clara Brasil Leite Mesquita
Lucas Eloy Veras Santos
Thalyson Costa Martins
Eduardo Martins de Sousa https://orcid.org/0000-0002-2506-169X

DOI:

https://doi.org/10.18593/evid.34545

Keywords:

Phytotherapy, Tuberculosis, Mycobacterium tuberculosis, Brasil

Abstract

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis, which mainly affects the lungs. Unwanted adverse effects, early abandonment of treatment due to its long duration, or even the development of bacteriological resistance are problems that stand out in the current pharmacological treatment against TB, which is why the use of herbal medicines has emerged as an efficient and practical therapeutic possibility in the Brazil, which justifies a screen search. The use of medicinal plants against TB in Brazil occurs mainly in contexts of family influence and transgenerational popular wisdom and, with this in mind, this study aims to carry out a systematic review of the literature to analyze the description, effectiveness, feasibility and variability of herbal medicines in TB treatment in the Brazilian context. This research is characterized as a systematic bibliographic review carried out from electronic databases, such as PubMed, VHL and Scielo from January 2013 to December 2022. The studies showed that the use of herbal medicines presented itself as a successful alternative in the fight against to TB as it presents great therapeutic efficacy, is financially accessible and has few adverse effects. Promising plants were identified for the production of drugs capable of acting simultaneously against tuberculosis and HIV. Some herbal medicines are only fully effective when used in conjunction with other vegetables. Despite the promising results presented by the studies, the patterns of clinical use of medicinal herbal medicines are deficient and further research is needed on the herbal phytomedicine interaction and clinical complications.

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