Polimorfismos no gene receptor de Vitamina D e a suscetibilidade e progressão da doença renal crônica

Jalila Andréa Sampaio Bittencourt; Naruna Aritana Costa Melo; Margareth Santos Costa Penha; Maria Eduarda Azevedo; Lucas Almeida das Chagas; Yuri Armin Crispim de Moraes; Allan Kardec Duailibe Barros Filho

doi:10.18593/evid.34487

Authors

Jalila Andréa Sampaio Bittencourt Universidade Federal do Maranhão, Programa de Pós Graduação em Biotecnologia - RENORBIO, Laboratório de Processamento da Informação Biológica – PIB https://orcid.org/0000-0001-6294-8532
Naruna Aritana Costa Melo Universidade Estadual do Maranhão, Departamento de Ciências Biológicas, Laboratório de Genética e Biologia Molecular – GENBIMOL
Margareth Santos Costa Penha Universidade Ceuma, Departamento de Biomedicina, Laboratório de Ciências Biomédicas – LCBI https://orcid.org/0000-0002-7677-1827
Maria Eduarda Azevedo Universidade Federal do Maranhão, Departamento de Engenharia Elétrica, Laboratório de Processamento da Informação Biológica – PIB
Lucas Almeida das Chagas Universidade Federal de São Paulo. Programa de Pós-Graduação em Obstetrícia – Escola Paulista de Medicina https://orcid.org/0000-0002-5047-2300
Yuri Armin Crispim de Moraes Universidade Federal do Maranhão, Departamento de Engenharia Elétrica, Laboratório de Processamento da Informação Biológica – PIB https://orcid.org/0000-0001-7308-8291
Allan Kardec Duailibe Barros Filho Universidade Federal do Maranhão, Departamento de Engenharia Elétrica, Laboratório de Processamento da Informação Biológica – PIB

DOI:

https://doi.org/10.18593/evid.34487

Keywords:

Chronic Kidney Disease, Polymorphism, Gene VDR

Abstract

Chronic non-communicable diseases (NCD) are considered one of the biggest public health problems. Among them, chronic kidney disease (CKD) stands out, which is characterized by the alteration of renal function. As with CKD, hypovitaminosis D has also become an increasing public health problem in the population. Many factors can explain the low levels of this vitamin and its supplementation is commonly used as an auxiliary therapy in patients with CKD. However, the nephroprotective effects of vitamin D are mediated by the vitamin D receptor gene – VDR, and a genetic alteration in this receptor can reduce the effectiveness of treatments, worsening the disease prognosis. This work aimed to review studies that investigated the association between VDR gene polymorphisms and CKD susceptibility and progression in the last 10 years (between 2013 and 2023). Based on a search in the PUBMED, LILACS and COCHRANE databases, nine articles that investigated this association were included. Cardiometabolic effects, followed by end-stage renal disease, and osteodystrophy were the most frequently observed clinical outcomes. These outcomes are associated with the different polymorphisms of the VDR. Furthermore, studies of genetic associations to describe the effects of VDR gene polymorphism on CKD are needed.

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References

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