Fungal polysaccharides and their hypoglycemic potential to act as an adjuvant in the treatment of diabetes mellitus

Gabriel Macêdo Figueroa; Danilo Nascimento Costa; Alana Caise dos Anjos Miranda; Gildomar Lima Valasques Júnior; Tátilla Putumujú Santana  Mendes; Pâmala Évelin Pires Cedro

doi:10.18593/evid.32561

Autores

Gabriel Macêdo Figueroa Universidade Estadual do Sudoeste da Bahia
Danilo Nascimento Costa Universidade Estadual do Sudoeste da Bahia
Alana Caise dos Anjos Miranda Universidade Estadual de Feira de Santana
Gildomar Lima Valasques Júnior Universidade Estadual do Sudoeste da Bahia https://orcid.org/0000-0002-2877-5313
Tátilla Putumujú Santana Mendes Universidade Estadual do Sudoeste da Bahia
Pâmala Évelin Pires Cedro Universidade Estadual do Sudoeste da Bahia

DOI:

https://doi.org/10.18593/evid.32561

Palavras-chave:

Biotecnologia, Fungos, Hipoglicemiantes

Resumo

Diabetes mellitus é considerado um grave problema de saúde pública, pois afeta milhões de indivíduos e causa inúmeras complicações. Os constantes efeitos adversos das terapias convencionais para diabetes mellitus têm estimulado pesquisas que buscam novas formas de tratamento, prevenção e controle. Polissacarídeos obtidos de fungos são promissores como adjuvantes no controle do diabetes mellitus. Este estudo é uma revisão de literatura que buscou avaliar as propriedades hipoglicemiantes de polissacarídeos obtidos de fungos e compreender os principais mecanismos de ação envolvidos. Os principais mecanismos relatados nos estudos que resultaram na diminuição da glicemia foram a inibição de enzimas digestivas, como α-amilase e α-glicosidase, ação nas vias de sinalização IRS1, PI3K, JNK1, antioxidante, anti-inflamatória, capacidade hipolipidêmica e estimulação da microbiota intestinal.

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