E-ISSN 2674-6832 Archives in Biosciences & Health is an Open Access Journal, no article-processing charges, that belongs to University of West of Santa Catarina (Unoesc). This Journal aims to cover semestral review and research articles publications on interdisciplinary field, involving areas of Biosciences and Health.
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DEPRESSION IN MASTECTOMIZED WOMEM: A BRIEF REPORT
Only in the year 2018, over two million cases of breast cancer worldwide have been reported, often treated through mastectomy, showing the importance of the study of this procedure, in relation to the physical, psychological and spiritual sequelae of the patients. The objective was to evaluate how these sequels favor the development of post-surgery depression. A bibliometric research was developed in the Portal of Periodicals of the Coordination for the Improvement of Higher Education Personnel, using the following key words ["mastectomized women" and "depression"] 32 articles found. The results were submitted to the "peer-reviewed journals" filter and “Articles in English and Portuguese”, resulting in 10 selected articles that were then merged compiled with information collected from the official WHO and INCA websites to compose this work. Mastectomy aesthetically affects an important component of assertion of womanliness, sexuality and womanhood, post-surgical depression is a common reaction in these patients. Part of these consequences are of a sexual, affective, social and even altered bodily perception. The importance of family, social and professional support in the rehabilitation of these women is also emphasized. The review of these articles allowed us to verify the need to analyze the reconstruction of the breast in mastectomized women as a matter of mental health, and not only as an aesthetic desire for them.
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RELATIONSHIP BETWEEN THE ALLOY FREQUENCY OF THE T102C POLYMORPHISM OF THE 5HT2A GENE WITH ANTHROPOMETRIC AND CARDIOMETABOLIC MEASURES
Obesity is a disease characterized by excessive body fat. Among the neurobiological factors associated with obesity, the serotonergic system stands out. The neurotransmitter of these circuits is serotonin (5-HT). Decreased levels of 5-HT have been linked to increased desire to ingest sweets and carbohydrates. This study aims to verify the relationship of the 5HT2A T102C gene polymorphism with obesity and anthropometric parameters. Blood samples and anthropometric data were collected from 150 volunteers, divided between the control and obese groups. The results showed that for individuals with diastolic pressure (p = 0.3681), Estimated Mean Glycemia (GMe) (p = 0.0228) and Homeostatic Model Assessment (HOMA-IR-IR) (p = 0.001) all altered, a higher frequency of C alleles was observed. For normal GMe (p = 0.0270), a higher frequency of the T allele was observed. There was no difference for the allele distribution between the normal and altered groups for the parameters of Triglycerides, HDL cholesterol, total cholesterol, glycated hemoglobin and Insulin. The distribution of the alleles between the groups, normal diastolic pressure (p = 0.3681) and HOMA-IR (p = 0.9203) groups presented no difference. From the genotypic analyzes of the T102C polymorphism of the 5HT2A gene, it was possible to demonstrate a relationship between the presence of the C allele with biochemical and anthropometric markers related to obesity and hypertension.
TOXICOLOGICAL PROFILE AND BLOOD ALCOHOL CONTENT OF SUICIDE VICTIMS IN THE FAR WEST OF SANTA CATARINA
Suicide has been a subject of increasing concern and the toxicological and blood alcohol investigate in these victims is little studied. This study investigated the toxicological and blood alcohol profile of suicide victims in 27 municipalities in the extreme west of Santa Catarina. Aggregate time series study, with a survey of epidemiological data and analysis of expert reports by the Medical Legal Institute of all fatal victims of suicide, registered in the period between 2012 to 2016. Results: Males, aged 50-59 years, were the main victims and the hanging the main suicide method. The months of February and November, Sundays and the time of 08:00 to 11:59 were the moments of greater occurrences. Elevated levels of alcohol were observed in 23.97% of the victims and the main drugs found were benzodiazepines and tricyclic antidepressants. The results obtained in this study reinforce the concern regarding cases of suicide and an association between alcohol/drug use and suicidal practices. The data provide subsidies for elaboration and implementation of preventive actions. Professionals should be alert to signs of suicide, so that specialized help becomes a possible option, and is instrumental in reducing the number of suicides.
A NEW METHODOLOGY FOR DIAGNOSIS OF FANCONI ANEMIA BASED ON BIOLOGICAL DOSIMETRY
Fanconi Anemia (FA) is a syndrome associated with chromosomal fragility. Current laboratory tests to diagnose this disease are based on the scoring of chromosomal aberrations induced in peripheral blood lymphocytes by clastogenic chemical agents, mainly: diepoxybutane (DEB) or mitomycin C (MMC). This study evaluated an alternative test for the diagnosis of FA, in which ionizing radiation replaces DEB/MMC. Two groups were studied: normal and DEB-sensitive individuals. From each individual, samples of peripheral blood were irradiated using an electron linear accelerator. Following lymphocyte cultures, and slide preparation, metaphases were scored based on the same methodology for biological dosimetry, according to recommendations of the International Atomic Energy Agency. Our results emphasized a pattern of distribution of dicentrics, fragments, as well as abnormal chromosomal arrangements. The methodology of analysis here proposed permitted to distinguish normal from DEB-sensitive subjects.