RELATIONSHIP BETWEEN THE ALLOY FREQUENCY OF THE T102C POLYMORPHISM OF THE 5HT2A GENE WITH ANTHROPOMETRIC AND CARDIOMETABOLIC MEASURES
DOI:
https://doi.org/10.18593/abh.20573Keywords:
Obesity, 5HT2A, Polymorphism, Cholesterol, BMIAbstract
Obesity is a disease characterized by excessive body fat. Among the neurobiological factors associated with obesity, the serotonergic system stands out. The neurotransmitter of these circuits is serotonin (5-HT). Decreased levels of 5-HT have been linked to increased desire to ingest sweets and carbohydrates. This study aims to verify the relationship of the 5HT2A T102C gene polymorphism with obesity and anthropometric parameters. Blood samples and anthropometric data were collected from 150 volunteers, divided between the control and obese groups. The results showed that for individuals with diastolic pressure (p = 0.3681), Estimated Mean Glycemia (GMe) (p = 0.0228) and Homeostatic Model Assessment (HOMA-IR-IR) (p = 0.001) all altered, a higher frequency of C alleles was observed. For normal GMe (p = 0.0270), a higher frequency of the T allele was observed. There was no difference for the allele distribution between the normal and altered groups for the parameters of Triglycerides, HDL cholesterol, total cholesterol, glycated hemoglobin and Insulin. The distribution of the alleles between the groups, normal diastolic pressure (p = 0.3681) and HOMA-IR (p = 0.9203) groups presented no difference. From the genotypic analyzes of the T102C polymorphism of the 5HT2A gene, it was possible to demonstrate a relationship between the presence of the C allele with biochemical and anthropometric markers related to obesity and hypertension.
Downloads
References
Bickerdike MJ. 5-HT 2C Receptor Agonists as Potential Drugs for the Treatment of Obesity. Current. 2003;885-97, 2003.
World Health Organization. Obesity: preventing and managing the global epidemic
Report of a WHO Consultation (WHO Technical Report Series 894). 2000.
Bechtholt AJ, Smith K, Gaughan S, Lucki I. Sucrose intake and fasting glucose levels in 5-HT 1A and 5-HT 1B receptor mutant mice. Physiology & behavior. 2008;93:659-65.
Voigt JP, Fink H. Serotonin controlling feeding and satiety. Behavioural Brain Research. 2015;277:14-31.
Feijó FDM, Bertoluci MC, Reis C. Serotonina e controle hipotalâmico da fome: uma revisão. Rev. Assoc. Med. Bras. 2011;57(51):74-77.
Naves A, Paschoal VCP. Regulação funcional da obesidade. ConScientiae Saúde. 2007;6(1):189-99.
Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, et al. Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology. 2008;149(3):1323-28.
Rossi L, Tirapegui J. Implicações do sistema serotoninérgico no exercício físico. Arq Bras Endocrinol Metab. 2004;48(2):227-33.
Yuan X, Yamada K, Ishiyama-Shigemoto S, Koyama W, Nonaka K. Identification of polymorphic loci in the promoter region of the serotonin 5-HT2C receptor gene and their association with obesity and type II diabetes. Diabetologia. 2000;43(3):373-6.
Polesskaya OO, Sokolov BP. Differential expression of the “C” and “T” alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. J. Neurosci. Res. 2002;67(6):812-22.
Mistry KG, Gohil PV. 5-HT2A receptor: A newertarget for Obesity. Int. J. Pharmtech Res. 2011;3(4):2089-95, 2011.
World Health Organization. Obesity: preventing and managing the global epidemic. Report of a World Health Organization Consultation. World Health Organ Tech Rep Ser. 2000;894(1-12):1-253.
Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 1972;18(6):499-502.
Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, et al. Quantitative insulin sensitivity check inex: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85(7):2402-10.
Weiner JS, Lourie JA. Practical Human Biology. London: Academic Press; 1981. p. 439.
Matsuda JB et al. Polimorfismos dos genes do receptor de serotonina (5-HT2A) e da catecol-O-metiltransferase (COMT): fatores desencadeantes da fibromialgia? ver Bras Reumatol. 2010;50(2):141-45.
Khait VD, Huang YY, Zalsman G, Oquendo MA, Brent DA, Harkavy-Friedman JM, et al. Association of serotonin 5-HT2A receptor binding and the T102C polymorphism in depressed and healthy Caucasian subjects. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology. 2005;30(1):166-72.
Montero LF, De Castro QL. Obesidade: Controle Neural e Hormonal do Comportamento Alimentar Obesity: Neuro-hormonal controloffoodintake. Med. Biol. 2011;103:236-45.
Ferreira L, Gomes E. Estudo sobre a eficácia do uso de inibidores da recaptação de norepinefrina e serotonina no tratamento da obesidade (Sibutramina ®). Rev. Saúde e Pesq. 2009;2(3):363-69.
Ward SJ, Jackson C, Lefever TW, Tallarida RJ. Effects of a Cannabinoid 1 Receptor Antagonist and Serotonin 2C Receptor Agonist Alone and in Combination on Motivation for Palatable Food: A Dose-Addition Analysis Study in Mice. J Pharmacol Exp Ther. 2008;325(2):567-76.
Wade JM, Juneja P, MacKay AW, Graham J, Havel PJ, Tecott LH, et al. Synergistic impairment of glucose homeostasis in ob/ob mice lacking functional serotonin 2C receptors. Endocrinology. 2008;149(3):955-61.
Rowland NE, Mukherjee M, Robertson K. Effects of the cannabinoid receptor antagonist SR 141716, alone and in combination with dexfenfluramine or naloxone, on food intake in rats. Psychopharmacology. 2002;159(1):111-16.
Sanders-Bush E, Fentress H, Hazelwood L. Serotonin 5-ht2 receptors: molecular and genomic diversity. Mol. Interv. 2003;3(6):319-30.
Yamada S, Akita H, Kanazawa K, Ishida T, Hirata K, Ito K, et al. T102C polymorphism of the serotonin (5-HT) 2A receptor gene in patients with non-fatal acute myocardial infarction. Atherosclerosis. 2000;150(1)143-8.
Lopez-Esparza S, Berumen LC, Padilla K, Miledi R, García-Alcocer G. Expression of hippocampal serotonin receptors 5-HT2C and 5-HT5A in a rat model of diet-induced obesity supplemented with tryptophan. Int J Dev Neurosci. 2015;42:80-85.
Spadaro PA, Naug HL, Du Toit EF, Donner D, Colson NJ. A refined high carbohydrate diet is associated with changes in the serotonin pathway and visceral obesity. Genet. Res. 2015;97:23.
Weber ET, Andrade R. Htr2a gene and 5-HT2A receptor expression in the cerebral cortex studied using genetically modified mice. Front Neurosci. 2010;4:1-12.
Marston OJ, Heisler LK. Targeting the serotonin 2C receptor for the treatment of obesity and type 2 diabetes. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology. 2009;34(1):252-53.
Yamamoto M. et al. Interaction between serotonin 2A receptor and endothelin-1 variants in association with hypertension in Japanese. Hypertension research: official journal of the Japanese Society of Hypertension. 2006;29(4):227-32.
Downloads
Published
How to Cite
Issue
Section
License
Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho licenciado simultaneamente sob uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional.
