Properties of chitosan matrix composites with hydroxyapatite and carbon nanotubes, and their use in bone tissue engineering
DOI:
https://doi.org/10.18593/abh.19226Keywords:
Bone tissue engineering, Hydroxyapatite, Chitosan, Carbon nanotubesAbstract
There is a growing demand for bone grafts by various clinical sectors, such as aesthetic procedures, treatment of injuries and dentistry, the use of synthetic materials is shown to be good due to the availability and the reduction of risks that their use brings, among the materials that are used in the clinic can be cited the chitosan matrix composites (CHI) with hydroxyapatite (HA) and carbon nanotubes (CNTs), which uses materials that are already used in the clinic HA and CHI with an innovative material in the sector the CNTs. The aim was to analyze and compare data from the current state of the art of CHI matrix composites with HA and CNTs applied in bone tissue engineering. This study is based on a review of the specialized literature on articles in online scientific journals, with thematic issues related to the properties of the biocomposite on board. The influence of the use on the composite properties generated by the use of CNTs together with the HA in the CHI matrix, for biomedical applications, more specifically in bone tissue engineering, was observed. It was observed that with subtle increases of CNTs in the CH composite Ha composites, the bioactivity, osteoconduction, antibacterial activity, mechanical properties of the composites, changes in the nanotexturas, and a homogeneous distribution of the materials occur, potentiality of its use in more than one application within bone tissue engineering. In the present study it was possible to observe that CHI matrix composites with HA and CNTs present a combination of properties highlighting the potential for application in bone tissue engineering.
Downloads
References
Garcia CD, Pereira JD, Garcia VD. Doação e transplante de órgãos e tecidos. 1. ed. São Paulo: Segmento Farma editores Ltda; 2015.
Grémare A, Guduric V, Bareille R, Heroguez VL, Heureux SLN, Fricain JC, et al. Characterization of printed PLA scaffolds for bone tissue engineering. J. Biomed. Mater. Res. 2018; 106(4):887-94.
Maia M, Klein ES, Monje TV, Pagliosa C. Reconstrução da estrutura facial por biomateriais: revisão de literatura. Rev Bras Cir Plást. 2010; 25(3):566-72.
Mercuri EGF, Daniel AL, Machado RD. Modelo numérico micromecânico para scaffold de hidroxiapatita com cultura celular. 10th World Congress Computational Mechanics; 2014; 1(1). São Paulo: 2014.
Caselis JLV, Cervantes ER, Rosas ER. Crecimiento en fluido fisiológico simulado de hidroxiapatita sobre películas de PMMAsílice-CaO. Sociedad Mexicana de Ciencia y Tecnología de Superficies y Materiales. 2011; 24(3):92-5.
Shen G, Hu X, Guan G, Wang L. Surface Modification and Characterisation of Silk Fibroin Fabric Produced by the Layer-by-Layer Self-Assembly of Multilayer Alginate/Regenerated Silk Fibroin. The National Natural Science Foundation of China. 2015; 10(4):1-19.
Venkatesan J, Qianb ZJ, Ryua B, Kumar NA, Kim SK. Preparation and characterization of carbon nanotube-grafted-chitosan – Natural hydroxyapatite composite for bone tissue engineering. Carbohydr Polym. 2011; 83(2):569-77.
Jing Z, Wu Y, Su W, Tian M, Jiang W, Cao L, et al. Carbon Nanotube Reinforced Collagen/Hydroxyapatite Scaffolds Improve Bone Tissue Formation In Vitro and In Vivo. Ann Biomed Eng. 2017; 45(9):2075-87.
Zhu Y, Kelvin Xl, Yeung Wk, Chuc Pk, Wua S. Biofunctionalization of carbon nanotubes/chitosan hybrids on Ti implants by atom layer deposited ZnO nanostructures. Appl Surf Sci. 2017; 400(3):14-23.
Mesgar As, Mohammadi Z, Khosrovan S. Improvement of mechanical properties and in vitro bioactivity of freeze-dried gelatin/chitosan scaffolds by functionalized carbon nanotubes. Int J Polym Mater Po. 2018; 67(5):267-76.
Leung LH, Naguib HE. Viscoelastic properties of poly(«-caprolactone) – hydroxyapatite micro- and nano-composites. Polym Adv Technol. 2012; 24(2):144-50.
Beskardes IG, Demirtas TT, Durukan MD, Gümüsderelioglu M. Microwave-assisted fabrication of chitosan-hydroxyapatite superporous hydrogel composites asbone scaffolds. J Tissue Eng Regen Med. 2015; 2015(9):1233-46.
Chen L, Hu J, Shen X. Synthesis and characterization of chitosan–multiwalled carbon nanotubes/hydroxyapatite nanocomposites for bone tissue engineering. J Mater Sci Mater Med. 2013; 24(8):1843-51.
Liu Y, Tang J, Chen X, Xin Jh. Decoration of carbon nanotubes with chitosan. Carbon. 2005; 43(15):3178-80.
Shi YY, Li MG, Liu Q, Jia JZ, Xu XC, Cheng Y, Zheng YF.Electrophoretic deposition of graphene oxide reinforced chitosan–hydroxyapatite nanocomposite coatings on Ti substrate. J Mater Sci Mater Med. 2016; 27(48):1-13.
Venugopal, G, Veetil JC, Raghavan N, Singh V, Kuma A, Mukkannan A. Nano-dynamic mechanical and thermal responses of single-walled carbon nanotubes reinforced polymer nanocomposite thinfilms. J Alloy Compd. 2016; 668(b):454-9.
Wang FW, Shen L, Zhang WD, Tong YJ. Preparation and Mechanical Properties of Chitosan/Carbon Nanotubes Composites. Biomacromolecules. 2005; 6(6):3067-72.
Downloads
Published
How to Cite
Issue
Section
License
Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho licenciado simultaneamente sob uma Licença Creative Commons - Atribuição-NãoComercial 4.0 Internacional.
